An algorithm to detect and communicate the differences in computational models describing biological systems.

ABSTRACT:

Motivation

Repositories support the reuse of models and ensure transparency about results in publications linked to those models. With thousands of models available in repositories, such as the BioModels database or the Physiome Model Repository, a framework to track the differences between models and their versions is essential to compare and combine models. Difference detection not only allows users to study the history of models but also helps in the detection of errors and inconsistencies. Existing repositories lack algorithms to track a model's development over time.

Results

Focusing on SBML and CellML, we present an algorithm to accurately detect and describe differences between coexisting versions of a model with respect to (i) the models' encoding, (ii) the structure

SUBMITTER: Scharm M 

PROVIDER: S-EPMC4743622 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature