Ontology highlight
ABSTRACT:
SUBMITTER: Brock JS
PROVIDER: S-EPMC4743789 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Brock Joseph S JS Hamberg Mats M Balagunaseelan Navisraj N Goodman Michael M Morgenstern Ralf R Strandback Emilia E Samuelsson Bengt B Rinaldo-Matthis Agnes A Haeggström Jesper Z JZ
Proceedings of the National Academy of Sciences of the United States of America 20160111 4
Microsomal prostaglandin E2 synthase type 1 (mPGES-1) is responsible for the formation of the potent lipid mediator prostaglandin E2 under proinflammatory conditions, and this enzyme has received considerable attention as a drug target. Recently, a high-resolution crystal structure of human mPGES-1 was presented, with Ser-127 being proposed as the hydrogen-bond donor stabilizing thiolate anion formation within the cofactor, glutathione (GSH). We have combined site-directed mutagenesis and activi ...[more]