Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.

ABSTRACT:

Aims/hypothesis

Epidemiological studies in Pima Indians identified elevated levels of HDL-cholesterol (HDL-C) as a protective factor against type 2 diabetes risk in women. We assessed whether HDL-C-associated single-nucleotide polymorphisms (SNPs) also associate with type 2 diabetes in female Pima Indians.

Methods

Twenty-one SNPs in established HDL-C loci were initially analysed in 2,675 full-heritage Pima Indians. SNPs shown to associate with HDL-C (12 SNPs) were assessed for association with type 2 diabetes in 7,710 Pima Indians (55.6% female sex). The CETP locus provided the strongest evidence for association with HDL-C and was further interrogated by analysing tag SNPs.

Results

Twelve of the 21 SNPs analysed had a significant association with HDL-C in Pima Indians

SUBMITTER: Nair AK 

PROVIDER: S-EPMC4744100 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature