Subfertility increases risk of testicular cancer: evidence from population-based semen samples.

ABSTRACT:

Objective

To further understand the association between semen quality and cancer risk by means of well defined semen parameters.

Design

Retrospective cohort study.

Setting

Not applicable.

Patient(s)

A total of 20,433 men who underwent semen analysis (SA) and a sample of 20,433 fertile control subjects matched by age and birth year.

Intervention(s)

None.

Main outcome measure(s)

Risk of all cancers as well as site-specific results for prostate cancer, testicular cancer, and melanoma.

Result(s)

Compared with fertile men, men with SA had an increased risk of testicular cancer (hazard rate [HR] 3.3). When the characterization of infertility was refined using individual semen parameters, we found that oligozoospermic men had an increased risk of

SUBMITTER: Hanson HA 

PROVIDER: S-EPMC4744156 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature