Advances in immunotherapy for melanoma.
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ABSTRACT:
SUBMITTER: Redman JM
PROVIDER: S-EPMC4744430 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Advances in immunotherapy for melanoma.
Redman Jason M JM Gibney Geoffrey T GT Atkins Michael B MB
BMC medicine 20160206
In recent years, the introduction and Federal Drug Administration approval of immune checkpoint inhibitor antibodies has dramatically improved the clinical outcomes for patients with advanced melanoma. These antagonist monoclonal antibodies are capable of unleashing dormant or exhausted antitumor immunity, which has led to durable complete and partial responses in a large number of patients. Ipilimumab targets the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) receptor. Nivolumab and pembr ...[more]
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