Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC4744498 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Chen Yuhong Y Zheng Yongwei Y You Xiaona X Yu Mei M Fu Guoping G Su Xinlin X Zhou Fen F Zhu Wen W Wu Zhihong Z Zhang Jing J Wen Renren R Wang Demin D
Journal of immunology (Baltimore, Md. : 1950) 20160115 4
The three major Ras members, Kras, Hras, and Nras, are highly homologous and individual Ras genes can have distinct biological functions. Embryonic lethality of Kras-deficient mice precludes study of the biological functions of this Ras family member. In this study, we generated and examined mice with hematopoietic-specific deletion of Kras and bone marrow (BM) chimeric mice with B cell-specific targeted deletion of Kras. Hematopoietic-specific deletion of Kras impaired early B cell development ...[more]