Ontology highlight
ABSTRACT:
SUBMITTER: Peng W
PROVIDER: S-EPMC4744499 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Peng Weiyi W Chen Jie Qing JQ Liu Chengwen C Malu Shruti S Creasy Caitlin C Tetzlaff Michael T MT Xu Chunyu C McKenzie Jodi A JA Zhang Chunlei C Liang Xiaoxuan X Williams Leila J LJ Deng Wanleng W Chen Guo G Mbofung Rina R Lazar Alexander J AJ Torres-Cabala Carlos A CA Cooper Zachary A ZA Chen Pei-Ling PL Tieu Trang N TN Spranger Stefani S Yu Xiaoxing X Bernatchez Chantale C Forget Marie-Andree MA Haymaker Cara C Amaria Rodabe R McQuade Jennifer L JL Glitza Isabella C IC Cascone Tina T Li Haiyan S HS Kwong Lawrence N LN Heffernan Timothy P TP Hu Jianhua J Bassett Roland L RL Bosenberg Marcus W MW Woodman Scott E SE Overwijk Willem W WW Lizée Gregory G Roszik Jason J Gajewski Thomas F TF Wargo Jennifer A JA Gershenwald Jeffrey E JE Radvanyi Laszlo L Davies Michael A MA Hwu Patrick P
Cancer discovery 20151208 2
<h4>Unlabelled</h4>T cell-mediated immunotherapies are promising cancer treatments. However, most patients still fail to respond to these therapies. The molecular determinants of immune resistance are poorly understood. We show that loss of PTEN in tumor cells in preclinical models of melanoma inhibits T cell-mediated tumor killing and decreases T-cell trafficking into tumors. In patients, PTEN loss correlates with decreased T-cell infiltration at tumor sites, reduced likelihood of successful T- ...[more]