Ontology highlight
ABSTRACT:
SUBMITTER: Diamond EL
PROVIDER: S-EPMC4744547 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Diamond Eli L EL Durham Benjamin H BH Haroche Julien J Yao Zhan Z Ma Jing J Parikh Sameer A SA Wang Zhaoming Z Choi John J Kim Eunhee E Cohen-Aubart Fleur F Lee Stanley Chun-Wei SC Gao Yijun Y Micol Jean-Baptiste JB Campbell Patrick P Walsh Michael P MP Sylvester Brooke B Dolgalev Igor I Aminova Olga O Heguy Adriana A Zappile Paul P Nakitandwe Joy J Ganzel Chezi C Dalton James D JD Ellison David W DW Estrada-Veras Juvianee J Lacouture Mario M Gahl William A WA Stephens Philip J PJ Miller Vincent A VA Ross Jeffrey S JS Ali Siraj M SM Briggs Samuel R SR Fasan Omotayo O Block Jared J Héritier Sebastien S Donadieu Jean J Solit David B DB Hyman David M DM Baselga José J Janku Filip F Taylor Barry S BS Park Christopher Y CY Amoura Zahir Z Dogan Ahmet A Emile Jean-Francois JF Rosen Neal N Gruber Tanja A TA Abdel-Wahab Omar O
Cancer discovery 20151113 2
<h4>Unlabelled</h4>Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (non-LCH), respectively. The discovery of BRAF(V600E) mutations in approximately 50% of these patients provided the first molecular therapeutic target in histiocytosis. However, recurrent driving mutations in the majority of patients with BRAF(V600E)-w ...[more]