Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection.
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ABSTRACT:
SUBMITTER: Hesse S
PROVIDER: S-EPMC4744919 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection.
Hesse Shayla S Neill Frederick H FH Estes Mary K MK Shanker Sreejesh S Prasad B V Venkataram BV Ferreira Jennifer J Atmar Robert L RL
Clinical and vaccine immunology : CVI 20151209 2
The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74.5% and >95%, respectively, for identifying GI.1 norovirus infection among persons who received either a monovalent GI.1 norovirus virus-like particle (VLP) vaccine or placebo by the intranasal route f ...[more]
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