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A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development.

ABSTRACT: Radiation-induced lung injury is highly complex and characterized by multiple pathologies, which occur over time and sporadically throughout the lung. This complexity makes biomarker investigations and medical countermeasure screenings challenging. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has the ability to resolve differences spatially in molecular profiles within the lung following radiation exposure and can aid in biomarker identification and pharmaceutical efficacy investigations. MALDI-MSI was applied to the investigation of a whole-thorax lung irradiation model in non-human primates (NHP) for lipidomic analysis and medical countermeasure distribution.

SUBMITTER: Carter CL

PROVIDER: S-EPMC4745118 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development.

Carter Claire L CL Jones Jace W JW Barrow Kory K Kieta Kaitlyn K Taylor-Howell Cheryl C Kearney Sean S Smith Cassandra P CP Gibbs Allison A Farese Ann M AM MacVittie Thomas J TJ Kane Maureen A MA

Health physics 20151101 5

Radiation-induced lung injury is highly complex and characterized by multiple pathologies, which occur over time and sporadically throughout the lung. This complexity makes biomarker investigations and medical countermeasure screenings challenging. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has the ability to resolve differences spatially in molecular profiles within the lung following radiation exposure and can aid in biomarker identification and pharmaceu ...[more]

PMID: 26425906

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