HBV preS2 promotes the expression of TAZ via miRNA-338-3p to enhance the tumorigenesis of hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC4745710 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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HBV preS2 promotes the expression of TAZ via miRNA-338-3p to enhance the tumorigenesis of hepatocellular carcinoma.
Liu Peng P Zhang Hualin H Liang Xiaohong X Ma Hongxin H Luan Fang F Wang Bo B Bai Fuxiang F Gao Lifen L Ma Chunhong C
Oncotarget 20151001 30
Transactivators encoded by HBV, including HBx and preS2, play critical role in hepatocellular carcinoma (HCC). YAP, a downstream effector of the Hippo pathway, is involved in hepatocarcinogenesis mediated by HBx. Here, we investigated whether preS2, another transactivator encoded by HBV, regulates the Hippo pathway to promote HCC. We found that preS2 overexpression upregulated TAZ, a downstream effector of the Hippo pathway, at protein level but not at mRNA level. preS2 suppressed miRNA-338-3p e ...[more]
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