TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma.
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ABSTRACT:
SUBMITTER: Sang Y
PROVIDER: S-EPMC4745723 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma.
Sang Yi Y Chen Ming-Yuan MY Luo Donghua D Zhang Ru-Hua RH Wang Li L Li Mei M Luo Rongzhen R Qian Chao-Nan CN Shao Jian-Yong JY Zeng Yi-Xin YX Kang Tiebang T
Oncotarget 20151001 30
Metastasis is the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC). However, the molecular mechanisms of NPC metastasis are poorly understood. Here, using our customized gene microarray containing all of the known human transcription factors and the current markers for epithelial-mesenchymal transition, we report that TEL2 was down-regulated in highly metastatic NPC cells and the metastatic tissues in lymph node. Mechanistically, TEL2 inhibits the cell migration a ...[more]
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