Unknown

Dataset Information

0

MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1.


ABSTRACT: Hepatocellular carcinoma (HCC) is a worldwide malignance and displays marked vascular abnormalities and active metastasis. MicroRNAs (miRNAs) have been shown to play important roles in regulating tumor properties in cancer, however, whether miR-497 contributes to HCC angiogenesis or metastasis remains unclear. In this study, we found that miR-497 was significantly down-regulated in HCC tissue samples and cell lines. Gain-of-function and loss-of-function studies revealed that miR-497 could repress both the pro-angiogenic and metastatic ability of HCC cells. Subsequent investigations disclosed that miR-497 directly inhibited the 3'-untranslated regions (UTRs) of vascular endothelial growth factor A (VEGFA) and astrocyte elevated gene-1 (AEG-1). Furthermore, overexpression of these targets antagonized the function of miR-497. Based on nude mouse models, we demonstrated that overexpression of miR-497 significantly repressed microvessel densities in xenograft tumors and reduced pulmonary metastasis. In conclusion, our findings indicate that miR-497 downregulation contributes to angiogenesis and metastasis in HCC.

SUBMITTER: Yan JJ 

PROVIDER: S-EPMC4745744 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1.

Yan Jing-Jun JJ   Zhang Yu-Nan YN   Liao Jia-Zhi JZ   Ke Kun-peng KP   Chang Ying Y   Li Pei-Yuan PY   Wang Min M   Lin Ju-Sheng JS   He Xing-Xing XX  

Oncotarget 20151001 30


Hepatocellular carcinoma (HCC) is a worldwide malignance and displays marked vascular abnormalities and active metastasis. MicroRNAs (miRNAs) have been shown to play important roles in regulating tumor properties in cancer, however, whether miR-497 contributes to HCC angiogenesis or metastasis remains unclear. In this study, we found that miR-497 was significantly down-regulated in HCC tissue samples and cell lines. Gain-of-function and loss-of-function studies revealed that miR-497 could repres  ...[more]

Similar Datasets

| S-EPMC9769451 | biostudies-literature
| S-EPMC5041945 | biostudies-other
| S-EPMC5799159 | biostudies-literature
| S-EPMC9781440 | biostudies-literature
| S-EPMC6785451 | biostudies-literature
| S-EPMC9279733 | biostudies-literature
| S-EPMC7004514 | biostudies-literature
| S-EPMC5629759 | biostudies-literature
| S-EPMC5342721 | biostudies-literature
| S-EPMC10704985 | biostudies-literature