Expression of high affinity folate receptor in breast cancer brain metastasis.
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ABSTRACT:
SUBMITTER: Leone JP
PROVIDER: S-EPMC4745802 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Expression of high affinity folate receptor in breast cancer brain metastasis.
Leone José Pablo JP Bhargava Rohit R Theisen Brian K BK Hamilton Ronald L RL Lee Adrian V AV Brufsky Adam M AM
Oncotarget 20151001 30
High affinity folate receptor (HFR) can be overexpressed in breast cancer and is associated with poor prognosis, however the expression in breast cancer brain metastases (BCBM) is unknown. The aim of this study was to analyze the rate of HFR expression in BCBM and its role in the prognosis of this high-risk cohort. We analyzed 19 brain metastasis (BM) and 13 primary tumors (PT) from a total of 25 patients. HFR status was assessed by immunohistochemistry. Median follow-up was 4.2 years (range 0.6 ...[more]
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