Ontology highlight
ABSTRACT:
SUBMITTER: Zhang JQ
PROVIDER: S-EPMC4745910 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhang Jia-Qing JQ Gao Bin-Wen BW Wang Jing J Ren Qiao-Ling QL Chen Jun-Feng JF Ma Qiang Q Zhang Zi-Jing ZJ Xing Bao-Song BS
Oxidative medicine and cellular longevity 20160119
Reactive oxygen species (ROS) are closely related to the follicular granulosa cell apoptosis. Grape seed procyanidin B2 (GSPB2) has been reported to possess potent antioxidant activity. However, the GSPB2-mediated protective effects and the underlying molecular mechanisms in granulosa cell apoptosis process remain unknown. In this study, we showed for the first time that GSPB2 treatment decreased FoxO1 protein level, improved granulosa cell viability, upregulated LC3-II protein level, and reduce ...[more]