Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.
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ABSTRACT:
SUBMITTER: Schick UM
PROVIDER: S-EPMC4746331 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans.
Schick Ursula M UM Jain Deepti D Hodonsky Chani J CJ Morrison Jean V JV Davis James P JP Brown Lisa L Sofer Tamar T Conomos Matthew P MP Schurmann Claudia C McHugh Caitlin P CP Nelson Sarah C SC Vadlamudi Swarooparani S Stilp Adrienne A Plantinga Anna A Baier Leslie L Bien Stephanie A SA Gogarten Stephanie M SM Laurie Cecelia A CA Taylor Kent D KD Liu Yongmei Y Auer Paul L PL Franceschini Nora N Szpiro Adam A Rice Ken K Kerr Kathleen F KF Rotter Jerome I JI Hanson Robert L RL Papanicolaou George G Rich Stephen S SS Loos Ruth J F RJ Browning Brian L BL Browning Sharon R SR Weir Bruce S BS Laurie Cathy C CC Mohlke Karen L KL North Kari E KE Thornton Timothy A TA Reiner Alex P AP
American journal of human genetics 20160121 2
Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the Hispanic Community Health Study/Study of Latinos by using a mixed-model method that accounts for admixture and family relationships. We discovered and replicated associations with five genes (ACTN1, ETV7, GABBR1-MOG, MEF2C, and ZBTB9-BAK1). Our strongest association was with Amerindian-specific variant rs117672662 (p value = 1.16 × 10(-28)) i ...[more]
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