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Superparamagnetic iron oxide nanoparticle micelles stabilized by recombinant oleosin for targeted magnetic resonance imaging.

ABSTRACT: Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle-loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody-oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets.

SUBMITTER: Vargo KB 

PROVIDER: S-EPMC4746475 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Superparamagnetic iron oxide nanoparticle micelles stabilized by recombinant oleosin for targeted magnetic resonance imaging.

Vargo Kevin B KB   Zaki Ajlan Al AA   Warden-Rothman Robert R   Tsourkas Andrew A   Hammer Daniel A DA  

Small (Weinheim an der Bergstrasse, Germany) 20141122 12

Recombinant surfactants present a new platform for stabilizing and targeting nanoparticle imaging agents. Superparamagnetic iron oxide nanoparticle-loaded micelles for MRI contrast are stabilized by an engineered variant of the naturally occurring protein oleosin and targeted using a Her2/neu affibody-oleosin fusion. The recombinant oleosin platform allows simple targeting and the ability to easily swap the ligand for numerous targets. ...[more]

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