Genome-wide association study of serum iron phenotypes in premenopausal women of European descent.
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ABSTRACT:
SUBMITTER: Koller DL
PROVIDER: S-EPMC4746500 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study of serum iron phenotypes in premenopausal women of European descent.
Koller Daniel L DL Imel Erik A EA Lai Dongbing D Padgett Leah R LR Acton Dena D Gray Amie A Peacock Munro M Econs Michael J MJ Foroud Tatiana T
Blood cells, molecules & diseases 20151203
A genome-wide association study was performed on 1130 premenopausal women to detect common variants associated with three serum iron-related phenotypes. Total iron binding capacity was strongly associated (p=10(-14)) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p=4×10(-7)), which encodes the human hemochromatosis gene. Association was also detected between percent iron saturation (p=10(-8)) and variants in the chromosome 6 re ...[more]
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