Ontology highlight
ABSTRACT:
SUBMITTER: Kaur P
PROVIDER: S-EPMC4746636 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kaur Parminder P Wu Dong D Lin Jiangguo J Countryman Preston P Bradford Kira C KC Erie Dorothy A DA Riehn Robert R Opresko Patricia L PL Wang Hong H
Scientific reports 20160209
Shelterin protein TRF2 modulates telomere structures by promoting dsDNA compaction and T-loop formation. Advancement of our understanding of the mechanism underlying TRF2-mediated DNA compaction requires additional information regarding DNA paths in TRF2-DNA complexes. To uncover the location of DNA inside protein-DNA complexes, we recently developed the Dual-Resonance-frequency-Enhanced Electrostatic force Microscopy (DREEM) imaging technique. DREEM imaging shows that in contrast to chromatin w ...[more]