Quantifying the cooperative subunit action in a multimeric membrane receptor.
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ABSTRACT:
SUBMITTER: Wongsamitkul N
PROVIDER: S-EPMC4746656 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Quantifying the cooperative subunit action in a multimeric membrane receptor.
Wongsamitkul Nisa N Nache Vasilica V Eick Thomas T Hummert Sabine S Schulz Eckhard E Schmauder Ralf R Schirmeyer Jana J Zimmer Thomas T Benndorf Klaus K
Scientific reports 20160209
In multimeric membrane receptors the cooperative action of the subunits prevents exact knowledge about the operation and the interaction of the individual subunits. We propose a method that permits quantification of ligand binding to and activation effects of the individual binding sites in a multimeric membrane receptor. The power of this method is demonstrated by gaining detailed insight into the subunit action in olfactory cyclic nucleotide-gated CNGA2 ion channels. ...[more]
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