Nonhuman genetics. Strong male bias drives germline mutation in chimpanzees.
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ABSTRACT:
SUBMITTER: Venn O
PROVIDER: S-EPMC4746749 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Nonhuman genetics. Strong male bias drives germline mutation in chimpanzees.
Venn Oliver O Turner Isaac I Mathieson Iain I de Groot Natasja N Bontrop Ronald R McVean Gil G
Science (New York, N.Y.) 20140612 6189
Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10(-8) per base pair per generation, with every additional year of father's age contributing two mutations across the genome and males contributing three to four times as many mutations as females. To assess whether such patterns are shared with our closest living relatives, we sequenced the genomes of a nine-member pedigree of Western chimpanzees, P ...[more]
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