Ontology highlight
ABSTRACT:
SUBMITTER: Gong G
PROVIDER: S-EPMC4747105 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Gong Guohua G Song Moshi M Csordas Gyorgy G Kelly Daniel P DP Matkovich Scot J SJ Dorn Gerald W GW
Science (New York, N.Y.) 20151203 6265
In developing hearts, changes in the cardiac metabolic milieu during the perinatal period redirect mitochondrial substrate preference from carbohydrates to fatty acids. Mechanisms responsible for this mitochondrial plasticity are unknown. Here, we found that PINK1-Mfn2-Parkin-mediated mitophagy directs this metabolic transformation in mouse hearts. A mitofusin (Mfn) 2 mutant lacking PINK1 phosphorylation sites necessary for Parkin binding (Mfn2 AA) inhibited mitochondrial Parkin translocation, s ...[more]