Ontology highlight
ABSTRACT:
SUBMITTER: Yu GT
PROVIDER: S-EPMC4747210 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Yu Guang-Tao GT Bu Lin-Lin LL Huang Cong-Fa CF Zhang Wen-Feng WF Chen Wan-Jun WJ Gutkind J Silvio JS Kulkarni Ashok B AB Sun Zhi-Jun ZJ
Oncotarget 20151201 39
Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs) play key roles in the tumor immune suppressive network and tumor progression. However, precise roles of programmed death-1 (PD-1) in immunological functions of MDSCs and TAMs in head and neck squamous cell carcinoma (HNSCC) have not been clearly elucidated. In the present study, we show that PD-1 and PD-L1 levels were significantly higher in human HNSCC specimen than in normal oral mucosa. MDSCs and TAMs were charac ...[more]