Ontology highlight
ABSTRACT:
SUBMITTER: Singh BN
PROVIDER: S-EPMC4747240 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Singh Bhairab N BN Kawakami Yasuhiko Y Akiyama Ryutaro R Rasmussen Tara L TL Garry Mary G MG Gong Wuming W Das Satyabrata S Shi Xiaozhong X Koyano-Nakagawa Naoko N Garry Daniel J DJ
Cell reports 20151022 5
MicroRNAs (miRNAs) are known to regulate critical developmental stages during embryogenesis. Here, we defined an Etv2-miR-130a cascade that regulates mesodermal specification and determination. Ablation of Dicer in the Etv2-expressing precursors resulted in altered mesodermal lineages and embryonic lethality. We identified miR-130a as a direct target of Etv2 and demonstrated its role in the segregation of bipotent hemato-endothelial progenitors toward the endothelial lineage. Gain-of-function ex ...[more]