Ontology highlight
ABSTRACT:
SUBMITTER: Nagarajan S
PROVIDER: S-EPMC4747248 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Nagarajan Sankari S Hossan Tareq T Alawi Malik M Najafova Zeynab Z Indenbirken Daniela D Bedi Upasana U Taipaleenmäki Hanna H Ben-Batalla Isabel I Scheller Marina M Loges Sonja S Knapp Stefan S Hesse Eric E Chiang Cheng-Ming CM Grundhoff Adam A Johnsen Steven A SA
Cell reports 20140710 2
The estrogen receptor α (ERα) controls cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to control gene transcription. A deeper understanding of these transcriptional mechanisms may uncover therapeutic targets for ERα-dependent cancers. We show that BRD4 regulates ERα-induced gene expression by affecting elongation-associated phosphorylation of RNA polymerase II (RNAPII) and histone H2B monoubiquitination. Consistently, BRD4 activity is re ...[more]