Ontology highlight
ABSTRACT:
SUBMITTER: Hivert MF
PROVIDER: S-EPMC4747453 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Hivert Marie-France MF Christophi Costas A CA Franks Paul W PW Jablonski Kathleen A KA Ehrmann David A DA Kahn Steven E SE Horton Edward S ES Pollin Toni I TI Mather Kieren J KJ Perreault Leigh L Barrett-Connor Elizabeth E Knowler William C WC Florez Jose C JC
Diabetes 20151102 2
Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people with genetic enrichment for these IR variants respond differently to interventions that aim to improve insulin sensitivity. We built a genetic risk score (GRS) based on 17 established IR variants and effect sizes (weighted IR-GRS) in 2,713 participants of the Diabetes Prevention Program (DPP) with genet ...[more]