AKT1E¹?K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.
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ABSTRACT:
SUBMITTER: Malanga D
PROVIDER: S-EPMC4747507 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
AKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung Cancer.
Malanga Donatella D Belmonte Stefania S Colelli Fabiana F Scarfò Marzia M De Marco Carmela C Oliveira Duarte Mendes DM Mirante Teresa T Camastra Caterina C Gagliardi Monica M Rizzuto Antonia A Mignogna Chiara C Paciello Orlando O Papparella Serenella S Fagman Henrik H Viglietto Giuseppe G
PloS one 20160209 2
The hotspot AKT1E17K mutation in the pleckstrin homology domain of AKT1 occurs in approximately 0.6-2% of human lung cancers. Recently, we have demonstrated that AKT1E17K transforms immortalized human bronchial cells. Here by use of a transgenic Cre-inducible murine strain in the wild type Rosa26 (R26) locus (R26-AKT1E17K mice) we demonstrate that AKT1E17K is a bona-fide oncogene and plays a role in the development of lung cancer in vivo. In fact, we report that mutant AKT1E17K induces bronchial ...[more]
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