Ontology highlight
ABSTRACT:
SUBMITTER: Lungu C
PROVIDER: S-EPMC4747634 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Lungu C C Considine E E Zahir S S Ponsati B B Arrastia S S Hallett M M
European journal of neurology 20121112 3
<h4>Background and purpose</h4>Injectable botulinum neurotoxin (BoNT) is the principal effective treatment for blepharospasm (BSP). This trial explores the safety and efficacy of topical acetyl hexapeptide-8 (AH8), a competitive SNAP25 inhibitor, as a potential new therapy in BSP.<h4>Methods</h4>Double-blind, placebo-controlled, randomized trial of daily topical application of AH8 in 24 patients with BSP. The primary outcome was time to return to baseline Jankovic Blepharospasm Rating Scale (JBR ...[more]