Ontology highlight
ABSTRACT:
SUBMITTER: Dazert E
PROVIDER: S-EPMC4747770 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Dazert Eva E Colombi Marco M Boldanova Tujana T Moes Suzette S Adametz David D Quagliata Luca L Roth Volker V Terracciano Luigi L Heim Markus H MH Jenoe Paul P Hall Michael N MN
Proceedings of the National Academy of Sciences of the United States of America 20160119 5
Compensatory signaling pathways in tumors confer resistance to targeted therapy, but the pathways and their mechanisms of activation remain largely unknown. We describe a procedure for quantitative proteomics and phosphoproteomics on snap-frozen biopsies of hepatocellular carcinoma (HCC) and matched nontumor liver tissue. We applied this procedure to monitor signaling pathways in serial biopsies taken from an HCC patient before and during treatment with the multikinase inhibitor sorafenib. At di ...[more]