Optimization of RGD-Containing Cyclic Peptides against ?v?3 Integrin.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC4747864 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Optimization of RGD-Containing Cyclic Peptides against αvβ3 Integrin.
Wang Yan Y Xiao Wenwu W Zhang Yonghong Y Meza Leah L Tseng Harry H Takada Yoshikazu Y Ames James B JB Lam Kit S KS
Molecular cancer therapeutics 20151230 2
We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp-containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity. αvβ3 integrin is known to be overexpressed in many cancers and in tumor vasculature, and it has been established as a cancer therapeutic target. To further optimize LXW7, we have performed systematic structure-activity relationship studies. On the basis of the ...[more]
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