Ontology highlight
ABSTRACT:
SUBMITTER: Ikeda G
PROVIDER: S-EPMC4748220 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Ikeda Gentaro G Matoba Tetsuya T Nakano Yasuhiro Y Nagaoka Kazuhiro K Ishikita Ayako A Nakano Kaku K Funamoto Daiki D Sunagawa Kenji K Egashira Kensuke K
Scientific reports 20160210
Myocardial ischemia-reperfusion (IR) injury limits the therapeutic effects of early reperfusion therapy for acute myocardial infarction (MI), in which mitochondrial permeability transition pore (mPTP) opening plays a critical role. Our aim was to determine whether poly-lactic/glycolic acid (PLGA) nanoparticle-mediated mitochondrial targeting of a molecule that inhibits mPTP opening, cyclosporine A (CsA), enhances CsA-induced cardioprotection. In an in vivo murine IR model, intravenously injected ...[more]