Ontology highlight
ABSTRACT:
SUBMITTER: Rathore OS
PROVIDER: S-EPMC4748286 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Rathore Om Singh OS Faustino Alexandra A Prudêncio Pedro P Van Damme Petra P Cox Cymon J CJ Martinho Rui Gonçalo RG
Scientific reports 20160210
Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six distinct but highly conserved NATs, suggesting an increase in regulatory complexity of this modification during eukaryotic evolution. Despite this, and against our initial expectations, we determined that NAT diversification did not occur in the eukaryotes, as all six maj ...[more]