Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.
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ABSTRACT:
SUBMITTER: Stephens MD
PROVIDER: S-EPMC4749165 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Potentiation of <i>Francisella</i> Resistance to Conventional Antibiotics through Small Molecule Adjuvants.
Stephens Matthew D MD Hubble Veroncia B VB Ernst Robert K RK van Hoek Monique L ML Melander Roberta J RJ Cavanagh John J Melander Christian C
MedChemComm 20150930 1
A screen of 20 compounds identified small molecule adjuvants capable of potentiating anitbiotic activty against <i>Francisella philomiragia</i>. Analogue synthesis of an initial hit compound led to the discovery of a potentially new class of small molecule adjuvants containg an indole core. The lead compound was able to lower the MIC of colistin by 32-fold against intrinsically resistant <i>F. philomiragia</i>. ...[more]
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