Ontology highlight
ABSTRACT:
SUBMITTER: Wiley CD
PROVIDER: S-EPMC4749409 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Wiley Christopher D CD Velarde Michael C MC Lecot Pacome P Liu Su S Sarnoski Ethan A EA Freund Adam A Shirakawa Kotaro K Lim Hyung W HW Davis Sonnet S SS Ramanathan Arvind A Gerencser Akos A AA Verdin Eric E Campisi Judith J
Cell metabolism 20151210 2
Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function can drive age-related declines in the function of many post-mitotic tissues, but little is known about how mitochondrial dysfunction affects mitotic tissues. We show here that several manipulations that compromise mitochondrial function in proliferating human cells induce a senescence growth arrest with a modified SASP t ...[more]