Ontology highlight
ABSTRACT:
SUBMITTER: Lechman ER
PROVIDER: S-EPMC4749543 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Lechman Eric R ER Gentner Bernhard B Ng Stanley W K SW Schoof Erwin M EM van Galen Peter P Kennedy James A JA Nucera Silvia S Ciceri Fabio F Kaufmann Kerstin B KB Takayama Naoya N Dobson Stephanie M SM Trotman-Grant Aaron A Krivdova Gabriela G Elzinga Janneke J Mitchell Amanda A Nilsson Björn B Hermans Karin G KG Eppert Kolja K Marke Rene R Isserlin Ruth R Voisin Veronique V Bader Gary D GD Zandstra Peter W PW Golub Todd R TR Ebert Benjamin L BL Lu Jun J Minden Mark M Wang Jean C Y JC Naldini Luigi L Dick John E JE
Cancer cell 20160128 2
To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA, miR-126, high bioactivity aggregated all in vivo patient sample LSC activity into a single sorted population, tightly coupling miR-126 expression to LSC function. Through functional studies, miR-126 was found to restrain cell cycle progression, prevent differentiat ...[more]