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Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis.

ABSTRACT: The sea slug Hermissenda crassicornis (Mollusca, Gastropoda, Nudibranchia) has been studied extensively in associative learning paradigms. However, lack of genetic information previously hindered molecular-level investigations. Here, the Hermissenda brain transcriptome was sequenced and assembled de novo, producing 165,743 total transcripts. Orthologs of 95 genes implicated in learning were identified. These included genes for a serotonin receptor and a GABA-B receptor subunit that had not been previously described in molluscs, as well as an adenylyl cyclase gene not previously described in gastropods. This study illustrates the Hermissenda transcriptome's potential as an important genetic tool in future learning and memory research.

SUBMITTER: Tamvacakis AN

PROVIDER: S-EPMC4749734 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis.

Tamvacakis Arianna N AN Senatore Adriano A Katz Paul S PS

Learning & memory (Cold Spring Harbor, N.Y.) 20151116 12

The sea slug Hermissenda crassicornis (Mollusca, Gastropoda, Nudibranchia) has been studied extensively in associative learning paradigms. However, lack of genetic information previously hindered molecular-level investigations. Here, the Hermissenda brain transcriptome was sequenced and assembled de novo, producing 165,743 total transcripts. Orthologs of 95 genes implicated in learning were identified. These included genes for a serotonin receptor and a GABA-B receptor subunit that had not been ...[more]

PMID: 26572652

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Dataset Information

Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis.

Publications

Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis.

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