Ontology highlight
ABSTRACT:
SUBMITTER: Dos Passos GR
PROVIDER: S-EPMC4749822 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Dos Passos Giordani Rodrigues GR Sato Douglas Kazutoshi DK Becker Jefferson J Fujihara Kazuo K
Mediators of inflammation 20160128
Several animal and human studies have implicated CD4+ T helper 17 (Th17) cells and their downstream pathways in the pathogenesis of central nervous system (CNS) autoimmunity in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), challenging the traditional Th1-Th2 paradigm. Th17 cells can efficiently cross the blood-brain barrier using alternate ways from Th1 cells, promote its disruption, and induce the activation of other inflammatory cells in the CNS. A number of envi ...[more]