Ontology highlight
ABSTRACT:
SUBMITTER: Lin CC
PROVIDER: S-EPMC4749922 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Lin Chih-Chung CC Bradstreet Tara R TR Schwarzkopf Elizabeth A EA Jarjour Nicholas N NN Chou Chun C Archambault Angela S AS Sim Julia J Zinselmeyer Bernd H BH Carrero Javier A JA Wu Gregory F GF Taneja Reshma R Artyomov Maxim N MN Russell John H JH Edelson Brian T BT
The Journal of experimental medicine 20160201 2
The features that define autoreactive T helper (Th) cell pathogenicity remain obscure. We have previously shown that Th cells require the transcription factor Bhlhe40 to mediate experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Here, using Bhlhe40 reporter mice and analyzing both polyclonal and TCR transgenic Th cells, we found that Bhlhe40 expression was heterogeneous after EAE induction, with Bhlhe40-expressing cells displaying marked production of IFN-γ, IL ...[more]