Ontology highlight
ABSTRACT:
SUBMITTER: Lassalle L
PROVIDER: S-EPMC4749974 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Lassalle Louise L Engilberge Sylvain S Madern Dominique D Vauclare Pierre P Franzetti Bruno B Girard Eric E
Scientific reports 20160211
Glyoxylate accumulation within cells is highly toxic. In humans, it is associated with hyperoxaluria type 2 (PH2) leading to renal failure. The glyoxylate content within cells is regulated by the NADPH/NADH dependent glyoxylate/hydroxypyruvate reductases (GRHPR). These are highly conserved enzymes with a dual activity as they are able to reduce glyoxylate to glycolate and to convert hydroxypyruvate into D-glycerate. Despite the determination of high-resolution X-ray structures, the substrate rec ...[more]