Ontology highlight
ABSTRACT:
SUBMITTER: Popov VB
PROVIDER: S-EPMC4750414 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Popov Violeta B VB Jornayvaz Francois R FR Akgul Emin O EO Kanda Shoichi S Jurczak Michael J MJ Zhang Dongyan D Abudukadier Abulizi A Majumdar Sachin K SK Guigni Blas B Petersen Kitt Falk KF Manchem Vara Prasad VP Bhanot Sanjay S Shulman Gerald I GI Samuel Varman T VT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20151207 3
Although mutations in the Wnt/β-catenin signaling pathway are linked with the metabolic syndrome and type 2 diabetes in humans, the mechanism is unclear. High-fat-fed male C57BL/6 mice were treated for 4 wk with a 2'-O-methoxyethyl chimeric antisense oligonucleotide (ASO) to decrease hepatic and adipose expression of β-catenin. β-Catenin mRNA decreased by ≈80% in the liver and by 70% in white adipose tissue relative to control ASO-treated mice. β-Catenin ASO improved hepatic insulin sensitivity ...[more]