Ontology highlight
ABSTRACT:
SUBMITTER: Said JS
PROVIDER: S-EPMC4750709 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Said Joanna S JS Trybala Edward E Görander Staffan S Ekblad Maria M Liljeqvist Jan-Åke JÅ Jennische Eva E Lange Stefan S Bergström Tomas T
Antimicrobial agents and chemotherapy 20151207 2
Herpes simplex virus (HSV) and many other viruses, including HIV, initiate infection of host cells by binding to glycosaminoglycan (GAG) chains of cell surface proteoglycans. Although GAG mimetics, such as sulfated oligo- and polysaccharides, exhibit potent antiviral activities in cultured cells, the prophylactic application of these inhibitors as vaginal microbicides failed to protect women upon their exposure to HIV. A possible explanation for this failure is that sulfated oligo- and polysacch ...[more]