Ontology highlight
ABSTRACT:
SUBMITTER: Xiao M
PROVIDER: S-EPMC4750931 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Xiao Meng M Zhao Rui R Zhang Qi Q Fan Xin X O'Sullivan Matthew V N MV Li Dong-Fang DF Wang Xin-Ying XY Wu Hong-Long HL Kong Fanrong F Xu Ying-Chun YC
PloS one 20160211 2
The α-hemolysin, encoded by the hla gene, is a major virulence factor in S. aureus infections. Changes in key amino acid residues of α-hemolysin can result in reduction, or even loss, of toxicity. The aim of this study was to investigate the diversity of the hla gene sequence and the relationship of hla variants to the clonal background of S. aureus isolates. A total of 47 clinical isolates from China were used in this study, supplemented with in silico analysis of 318 well-characterized whole g ...[more]