Ontology highlight
ABSTRACT:
SUBMITTER: Ye CJ
PROVIDER: S-EPMC4751028 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20140901 6202
T lymphocyte activation by antigen conditions adaptive immune responses and immunopathologies, but we know little about its variation in humans and its genetic or environmental roots. We analyzed gene expression in CD4(+) T cells during unbiased activation or in T helper 17 (T(H)17) conditions from 348 healthy participants representing European, Asian, and African ancestries. We observed interindividual variability, most marked for cytokine transcripts, with clear biases on the basis of ancestry ...[more]