T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression.

ABSTRACT:

Background

Imaging biomarkers sensitive to Huntington's disease (HD) during the premanifest phase preceding motor diagnosis may accelerate identification and evaluation of potential therapies. For this purpose, quantitative MRI sensitive to tissue microstructure and metabolism may hold great potential. We investigated the potential value of T1ρ relaxation to detect pathological changes in premanifest HD (preHD) relative to other quantitative relaxation parameters.

Methods

Quantitative MR parametric mapping was used to assess differences between 50 preHD subjects and 26 age- and sex-matched controls. Subjects with preHD were classified into two progression groups based on their CAG-age product (CAP) score; a high and a low/moderate CAP group. Voxel-wise and region-of-interest

SUBMITTER: Wassef SN 

PROVIDER: S-EPMC4751081 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature