Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC4751388 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Chen Yingying Y Maskri Ouerdia O Chaminade Françoise F René Brigitte B Benkaroun Jessica J Godet Julien J Mély Yves Y Mauffret Olivier O Fossé Philippe P
The Journal of biological chemistry 20151214 7
An essential step of human immunodeficiency virus type 1 (HIV-1) reverse transcription is the first strand transfer that requires base pairing of the R region at the 3'-end of the genomic RNA with the complementary r region at the 3'-end of minus-strand strong-stop DNA (ssDNA). HIV-1 nucleocapsid protein (NC) facilitates this annealing process. Determination of the ssDNA structure is needed to understand the molecular basis of NC-mediated genomic RNA-ssDNA annealing. For this purpose, we investi ...[more]