Ontology highlight
ABSTRACT:
SUBMITTER: Jeong JK
PROVIDER: S-EPMC4751501 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Jeong Jae-Kyo JK Gurunathan Sangiliyandi S Kang Min-Hee MH Han Jae Woong JW Das Joydeep J Choi Yun-Jung YJ Kwon Deug-Nam DN Cho Ssang-Goo SG Park Chankyu C Seo Han Geuk HG Song Hyuk H Kim Jin-Hoi JH
Scientific reports 20160212
Solid tumors are frequently associated with resistance to chemotherapy because the fraction of hypoxic tumor cells is substantial. To understand the underlying mechanism of hypoxia on silver nanoparticle (AgNPs)-induced apoptosis, the expression of hypoxia-inducible factor (HIF)-1α, a hallmark of hypoxia, was measured in the presence and absence of AgNPs. The results showed that HIF-1α expression was upregulated after AgNPs treatment under both hypoxic and normoxic conditions. Cell viability ass ...[more]