Ontology highlight
ABSTRACT:
SUBMITTER: Sun S
PROVIDER: S-EPMC4751599 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Sun Shengyi S Lourie Rohan R Cohen Sara B SB Ji Yewei Y Goodrich Julia K JK Poole Angela C AC Ley Ruth E RE Denkers Eric Y EY McGuckin Michael A MA Long Qiaoming Q Duhamel Gerald E GE Simpson Kenneth W KW Qi Ling L
Molecular biology of the cell 20151202 3
Inflammatory bowel disease (IBD) is an incurable chronic idiopathic disease that drastically decreases quality of life. Endoplasmic reticulum (ER)-associated degradation (ERAD) is responsible for the clearance of misfolded proteins; however, its role in disease pathogenesis remains largely unexplored. Here we show that the expression of SEL1L and HRD1, the most conserved branch of mammalian ERAD, is significantly reduced in ileal Crohn's disease (CD). Consistent with this observation, laboratory ...[more]