Seqinspector: position-based navigation through the ChIP-seq data landscape to identify gene expression regulators.

ABSTRACT:

Background

The regulation of gene expression in eukaryotic cells is a complex process that involves epigenetic modifications and the interaction of DNA with multiple transcription factors. This process can be studied with unprecedented sensitivity using a combination of chromatin immunoprecipitation and next-generation DNA sequencing (ChIP-seq). Available ChIP-seq data can be further utilized to interpret new gene expression profiling experiments.

Results

Here, we describe seqinspector, a tool that accepts any set of genomic coordinates from ChIP-seq or RNA-seq studies to identify shared transcriptional regulators. The presented web resource includes a large collection of publicly available ChIP-seq and RNA-seq experiments (>1300 tracks) performed on transcription factors, h

SUBMITTER: Piechota M 

PROVIDER: S-EPMC4751710 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature