Unknown

Dataset Information

0

Clinical Implications of Mutations in the PI3K Pathway in HER2+ Breast Cancer: Prognostic or Predictive?


ABSTRACT: Recent advances in tumor genetics and drug development have led to the generation of a wealth of anti-cancer-targeted therapies. These drugs aim at targeting a particular vulnerability in the tumor generated in most cases as a result of dependence on an oncogene and/or loss of a tumor suppressor. Genes in the phosphoinositide 3-kinase (PI3K)/AKT pathway are the most frequently altered in human cancers. Aberrant activation of the PI3K/AKT pathway has been shown to confer resistance to HER2-targeted therapies. Several drugs targeting PI3K/ATK have been developed and are currently in clinical trials in different phases of clinical development, alone or in combination. The impact of mutations in the phosphoinositide 3-kinase (PI3K)/AKT pathway in HER2-amplified breast cancers will be the focus of this review.

SUBMITTER: Mayer IA 

PROVIDER: S-EPMC4751984 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Clinical Implications of Mutations in the PI3K Pathway in HER2+ Breast Cancer: Prognostic or Predictive?

Mayer Ingrid A IA  

Current breast cancer reports 20151010 4


Recent advances in tumor genetics and drug development have led to the generation of a wealth of anti-cancer-targeted therapies. These drugs aim at targeting a particular vulnerability in the tumor generated in most cases as a result of dependence on an oncogene and/or loss of a tumor suppressor. Genes in the phosphoinositide 3-kinase (PI3K)/AKT pathway are the most frequently altered in human cancers. Aberrant activation of the PI3K/AKT pathway has been shown to confer resistance to HER2-target  ...[more]

Similar Datasets

| S-EPMC7492871 | biostudies-literature
| S-EPMC9360227 | biostudies-literature
| S-EPMC10570672 | biostudies-literature
| S-EPMC6662906 | biostudies-literature
| S-EPMC7137211 | biostudies-literature
| S-EPMC4833894 | biostudies-other
| S-EPMC7081042 | biostudies-literature
| S-EPMC5524249 | biostudies-other
| S-EPMC4504492 | biostudies-literature
| S-EPMC5530949 | biostudies-literature