Ontology highlight
ABSTRACT:
SUBMITTER: Ma JF
PROVIDER: S-EPMC4752043 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Ma Ji-Fang JF Yang Fan F Mahida Saagar N SN Zhao Ling L Chen Xiaomin X Zhang Michael L ML Sun Zhijun Z Yao Yan Y Zhang Yi-Xin YX Zheng Gu-Yan GY Dong Jie J Feng Ming-Jun MJ Zhang Rui R Sun Jian J Li Shuo S Wang Qun-Shan QS Cao Huiqing H Benjamin Emelia J EJ Ellinor Patrick T PT Li Yi-Gang YG Tian Xiao-Li XL
Cardiovascular research 20160113 3
<h4>Aims</h4>Atrial fibrillation (AF) is a common arrhythmia with an important heritable aspect. The genetic factors underlying AF have not been fully elucidated.<h4>Methods and results</h4>We screened six candidate genes (CAV1, KCNJ2, KCNQ1, NKX2.5, PITX2, and TBX5) for novel mutations in 139 patients of Chinese descent with early-onset AF and 576 controls. Four missense TBX5 mutations, p.R355C, p.Q376R, p.A428S, and p.S372L, were identified in evolutionarily conserved regions. We did not find ...[more]